[HTML][HTML] Association of GM3 with Zap-70 induced by T cell activation in plasma membrane microdomains: GM3 as a marker of microdomains in human lymphocytes
T Garofalo, L Lenti, A Longo, R Misasi, V Mattei… - Journal of Biological …, 2002 - ASBMB
Recent evidence demonstrated that T cell activation leads to the redistribution of membrane
and intracellular kinase-rich raft microdomains at the site of TCR engagement. In this
investigation we demonstrated by high performance thin layer chromatography, gas
chromatographic, and mass spectrometric analyses that GM3 is the main ganglioside
constituent of these microdomains in human lymphocytes. Then we analyzed GM3
distribution and its interaction with the phosphorylation protein Zap-70. Human T …
and intracellular kinase-rich raft microdomains at the site of TCR engagement. In this
investigation we demonstrated by high performance thin layer chromatography, gas
chromatographic, and mass spectrometric analyses that GM3 is the main ganglioside
constituent of these microdomains in human lymphocytes. Then we analyzed GM3
distribution and its interaction with the phosphorylation protein Zap-70. Human T …