Cloning of zebrafish nkx6. 2 and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube
B Guner, RO Karlstrom - Gene Expression Patterns, 2007 - Elsevier
Sonic Hedgehog (Shh) signaling helps pattern the vertebrate neural tube, in part by
regulating the dorsal/ventral expression of a number of homeodomain containing
transcription factors. These Hh responsive genes have been divided into two classes, with
Class II genes being activated by Hh signaling and Class I genes being repressed by Hh
signaling. While the transcriptional response to varying Hh levels is well defined in chick and
mouse, it is only partially described in zebrafish, despite the fact that zebrafish has emerged …
regulating the dorsal/ventral expression of a number of homeodomain containing
transcription factors. These Hh responsive genes have been divided into two classes, with
Class II genes being activated by Hh signaling and Class I genes being repressed by Hh
signaling. While the transcriptional response to varying Hh levels is well defined in chick and
mouse, it is only partially described in zebrafish, despite the fact that zebrafish has emerged …