p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells
S Balasenthil, AA Sahin, CJ Barnes, RA Wang… - Journal of Biological …, 2004 - ASBMB
p21-activated kinase 1 (Pak1) has been shown recently to induce hyperplasia in the
mammary epithelium, a phenotype also manifested by overexpression of cyclin D1, a known
indicator of the proliferative stage. Here we investigated the role of the Pak1 pathway in the
expression of cyclin D1 using tissue culture models and transgenic mice expressing
activated Pak1 in mammary glands. We found that hyperplastic mammary glands from
catalytically active Pak1 transgenic mice exhibit a 5-to 7-fold increased expression of cyclin …
mammary epithelium, a phenotype also manifested by overexpression of cyclin D1, a known
indicator of the proliferative stage. Here we investigated the role of the Pak1 pathway in the
expression of cyclin D1 using tissue culture models and transgenic mice expressing
activated Pak1 in mammary glands. We found that hyperplastic mammary glands from
catalytically active Pak1 transgenic mice exhibit a 5-to 7-fold increased expression of cyclin …