Anaemia characterises patients with myelofibrosis harbouring MplW515L/K mutation
P Guglielmelli, A Pancrazzi… - British journal of …, 2007 - Wiley Online Library
P Guglielmelli, A Pancrazzi, G Bergamaschi, V Rosti, L Villani, E Antonioli, A Bosi, G Barosi…
British journal of haematology, 2007•Wiley Online LibraryThe clinical and haematological phenotype of patients with myelofibrosis harbouring
MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects,
18 (8· 2%) had an MPL mutation, four of which (22%) co‐existed with JAK2V617F mutation.
When compared with MPL wild‐type patients, irrespective of JAK2V617F status, those with
MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P= 0· 02),
presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P= 0· 002) and were …
MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects,
18 (8· 2%) had an MPL mutation, four of which (22%) co‐existed with JAK2V617F mutation.
When compared with MPL wild‐type patients, irrespective of JAK2V617F status, those with
MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P= 0· 02),
presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P= 0· 002) and were …
Summary
The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co‐existed with JAK2V617F mutation. When compared with MPL wild‐type patients, irrespective of JAK2V617F status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.
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