[HTML][HTML] Novel role for STIM1 as a trigger for calcium influx factor production
P Csutora, K Peter, H Kilic, KM Park, V Zarayskiy… - Journal of biological …, 2008 - ASBMB
STIM1 has been recently identified as a Ca 2+ sensor in endoplasmic reticulum (ER) and an
initiator of the store-operated Ca 2+ entry (SOCE) pathway, but the mechanism of SOCE
activation remains controversial. Here we focus on the early ER-delimited steps of the SOCE
pathway and demonstrate that STIM1 is critically involved in initiating of production of
calcium influx factor (CIF), a diffusible messenger that can deliver the signal from the stores
to plasma membrane and activate SOCE. We discovered that CIF production is tightly …
initiator of the store-operated Ca 2+ entry (SOCE) pathway, but the mechanism of SOCE
activation remains controversial. Here we focus on the early ER-delimited steps of the SOCE
pathway and demonstrate that STIM1 is critically involved in initiating of production of
calcium influx factor (CIF), a diffusible messenger that can deliver the signal from the stores
to plasma membrane and activate SOCE. We discovered that CIF production is tightly …