Histopathology of incipient intraepidermal squamous cell carcinoma (“actinic keratosis”)
CJ Cockerell - Journal of the American Academy of Dermatology, 2000 - Elsevier
BACKGROUND: Actinic keratoses (AKs) are proliferations of transformed, neoplastic
keratinocytes confined to the epidermis induced by exposure to ultraviolet (UV) radiation in
sunlight. They are extremely prevalent and are seen in most middle-aged to elderly
Caucasian persons with a history of significant sun exposure. These lesions are currently
termed AKs while they remain confined to the epidermis, but when they extend more deeply
to involve the papillary and/or reticular dermis, they are termed squamous cell carcinoma …
keratinocytes confined to the epidermis induced by exposure to ultraviolet (UV) radiation in
sunlight. They are extremely prevalent and are seen in most middle-aged to elderly
Caucasian persons with a history of significant sun exposure. These lesions are currently
termed AKs while they remain confined to the epidermis, but when they extend more deeply
to involve the papillary and/or reticular dermis, they are termed squamous cell carcinoma …
