Gene targeting to disrupt gene expression in a temporal and spatial manner in a specific
tissue using Cre recombinase-mediated gene inactivation has been proven to be useful to
study in vivo gene function. To delete genes specifically in neurons during the late phase of
brain development, we have generated transgenic mouse lines that express Cre
recombinase under the control of the murine neurofilament-H (mNF-H) gene promoter. In
this study, we report that one of these mouse lines expresses Cre recombinase specifically …