[HTML][HTML] Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and fortilin: the potential role of MCL1 as a fortilin chaperone
D Zhang, F Li, D Weidner, ZH Mnjoyan… - Journal of Biological …, 2002 - ASBMB
Myeloid cell leukemia 1 protein (MCL1) is an anti-apoptotic protein that is structurally related
to Bcl-2. Unlike other Bcl-2 family proteins that are constitutively expressed, MCL1 is
inducibly expressed in cells that are recently exposed to growth and differentiation stimuli.
Here, we report the identification of fortilin as a novel MCL1-interacting protein by screening
of a yeast two-hybrid library with MCL1 as bait. Fortilin specifically interacted with MCL1 both
in vitro andin vivo. The intracellular localization of fortilin was predominantly nuclear and …
to Bcl-2. Unlike other Bcl-2 family proteins that are constitutively expressed, MCL1 is
inducibly expressed in cells that are recently exposed to growth and differentiation stimuli.
Here, we report the identification of fortilin as a novel MCL1-interacting protein by screening
of a yeast two-hybrid library with MCL1 as bait. Fortilin specifically interacted with MCL1 both
in vitro andin vivo. The intracellular localization of fortilin was predominantly nuclear and …
