Protective effect of a tuberculosis subunit vaccine based on a fusion of antigen 85B and ESAT-6 in the aerosol guinea pig model
AW Olsen, A Williams, LM Okkels, G Hatch… - Infection and …, 2004 - Am Soc Microbiol
AW Olsen, A Williams, LM Okkels, G Hatch, P Andersen
Infection and immunity, 2004•Am Soc MicrobiolABSTRACT A fusion protein of antigen 85B (Ag85B) and ESAT-6 administered in cationic
lipid vesicles conferred a highly significant level of protection against Mycobacterium
tuberculosis in the guinea pig aerosol model of infection. The protection was manifested as
delayed clinical illness and prolonged survival. Neither Ag85B nor ESAT-6 (independently
or as a cocktail) induced significant protection in this model.
lipid vesicles conferred a highly significant level of protection against Mycobacterium
tuberculosis in the guinea pig aerosol model of infection. The protection was manifested as
delayed clinical illness and prolonged survival. Neither Ag85B nor ESAT-6 (independently
or as a cocktail) induced significant protection in this model.
Abstract
A fusion protein of antigen 85B (Ag85B) and ESAT-6 administered in cationic lipid vesicles conferred a highly significant level of protection against Mycobacterium tuberculosis in the guinea pig aerosol model of infection. The protection was manifested as delayed clinical illness and prolonged survival. Neither Ag85B nor ESAT-6 (independently or as a cocktail) induced significant protection in this model.
American Society for Microbiology