Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice
V Bhaskar, J Yin, AM Mirza, D Phan, S Vanegas… - Atherosclerosis, 2011 - Elsevier
OBJECTIVE: Atherosclerosis is a condition that is increasingly contributing to worldwide
mortality through complications such as stroke and myocardial infarction. IL-1β plays
multiple direct, local roles in the formation and stability of the atheroma by eliciting the
production of additional cytokines and proteolytic enzymes from macrophages, endothelial
cells (EC) and smooth muscle cells (SMC). We therefore tested whether an anti-IL-1β
antibody, XOMA 052, might inhibit the secretion of pro-atherogenic cytokines from …
mortality through complications such as stroke and myocardial infarction. IL-1β plays
multiple direct, local roles in the formation and stability of the atheroma by eliciting the
production of additional cytokines and proteolytic enzymes from macrophages, endothelial
cells (EC) and smooth muscle cells (SMC). We therefore tested whether an anti-IL-1β
antibody, XOMA 052, might inhibit the secretion of pro-atherogenic cytokines from …
