Human scribble accumulates in colorectal neoplasia in association with an altered distribution of β-catenin
Y Kamei, K Kito, T Takeuchi, Y Imai, R Murase, N Ueda… - Human pathology, 2007 - Elsevier
The loss of epithelial polarity and tissue architecture is a diagnostic feature of malignant
tumors. In Drosophila, genetic studies identified 3 neoplastic tumor suppressor genes
(nTSGs), and a loss of nTSGs has been shown to result in a disruption of apical-basal
polarity and neoplastic growth in epithelial cells. Scribble is one type of the Drosophila
nTSGs, which encodes a membrane-associated cytoplasmic protein containing the multi-
PDZ domain. In contrast to Drosophila scribble, the oncogenic roles of its mammalian …
tumors. In Drosophila, genetic studies identified 3 neoplastic tumor suppressor genes
(nTSGs), and a loss of nTSGs has been shown to result in a disruption of apical-basal
polarity and neoplastic growth in epithelial cells. Scribble is one type of the Drosophila
nTSGs, which encodes a membrane-associated cytoplasmic protein containing the multi-
PDZ domain. In contrast to Drosophila scribble, the oncogenic roles of its mammalian …
