Identification of a gadd45β 3′ enhancer that mediates SMAD3-and SMAD4-dependent transcriptional induction by transforming growth factor β
MB Major, DA Jones - Journal of Biological Chemistry, 2004 - ASBMB
GADD45β regulates cell growth, differentiation, and cell death following cellular exposure to
diverse stimuli, including DNA damage and transforming growth factor-β (TGFβ). We
examined how cells transduce the TGFβ signal from the cell surface to the gadd45β
genomic locus and describe how GADD45β contributes to TGFβ biology. Following an
alignment of gadd45β genomic sequences from multiple organisms, we discovered a novel
TGFβ-responsive enhancer encompassing the third intron of the gadd45β gene. Using three …
diverse stimuli, including DNA damage and transforming growth factor-β (TGFβ). We
examined how cells transduce the TGFβ signal from the cell surface to the gadd45β
genomic locus and describe how GADD45β contributes to TGFβ biology. Following an
alignment of gadd45β genomic sequences from multiple organisms, we discovered a novel
TGFβ-responsive enhancer encompassing the third intron of the gadd45β gene. Using three …
