Elimination of KATP channels in mouse islets results in elevated [U-13C] glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased γ-aminobutyric …
C Li, I Nissim, P Chen, C Buettger, H Najafi… - Journal of biological …, 2008 - ASBMB
Pancreatic beta cells are hyper-responsive to amino acids but have decreased glucose
sensitivity after deletion of the sulfonylurea receptor 1 (SUR1) both in man and mouse. It was
hypothesized that these defects are the consequence of impaired integration of amino acid,
glucose, and energy metabolism in beta cells. We used gas chromatography-mass
spectrometry methodology to study intermediary metabolism of SUR1 knock-out (SUR1-/-)
and control mouse islets with d-[U-13 C] glucose as substrate and related the results to …
sensitivity after deletion of the sulfonylurea receptor 1 (SUR1) both in man and mouse. It was
hypothesized that these defects are the consequence of impaired integration of amino acid,
glucose, and energy metabolism in beta cells. We used gas chromatography-mass
spectrometry methodology to study intermediary metabolism of SUR1 knock-out (SUR1-/-)
and control mouse islets with d-[U-13 C] glucose as substrate and related the results to …
