Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor
The Runx2 transcription factor is required for commitment of mesenchymal cells to bone
lineages and is a major regulator of osteoblast-specific gene expression. Runx2 is subject to
a number of post-transcriptional controls including selective proteolysis and
phosphorylation. We previously reported that Runx2 is phosphorylated and activated by the
ERK/MAPK pathway (Xiao, G., Jiang, D., Thomas, P., Benson, MD, Guan, K., Karsenty, G.,
and Franceschi, RT (2000) J. Biol. Chem. 275, 4453–4459). In this study, we used a …
lineages and is a major regulator of osteoblast-specific gene expression. Runx2 is subject to
a number of post-transcriptional controls including selective proteolysis and
phosphorylation. We previously reported that Runx2 is phosphorylated and activated by the
ERK/MAPK pathway (Xiao, G., Jiang, D., Thomas, P., Benson, MD, Guan, K., Karsenty, G.,
and Franceschi, RT (2000) J. Biol. Chem. 275, 4453–4459). In this study, we used a …
