Insulin-like growth factor (IGF) and IGF binding protein gene expression in multicystic renal dysplasia.
DG Matsell, T Bennett, RA Armstrong… - Journal of the …, 1997 - journals.lww.com
Multicystic dysplastic kidney disease is the most common form of renal dysplasia that leads
to ESRD in children. This study describes the histopathological changes of multicystic
dysplasia that occur from early fetal life to the postnatal period. At 14 wk gestation, early
cystic enlargement of various segments of the nephron have been identified, in addition to a
displaced metanephric blastema adjacent to zones of normal nephrogenesis. At later
stages, the predominant features include cyst enlargement with marked fibromuscular …
to ESRD in children. This study describes the histopathological changes of multicystic
dysplasia that occur from early fetal life to the postnatal period. At 14 wk gestation, early
cystic enlargement of various segments of the nephron have been identified, in addition to a
displaced metanephric blastema adjacent to zones of normal nephrogenesis. At later
stages, the predominant features include cyst enlargement with marked fibromuscular …
