[HTML][HTML] Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms
MJ Boucher, L Selander, L Carlsson… - Journal of Biological …, 2006 - ASBMB
The transcription factor IPF1/PDX1 plays a crucial role in both pancreas development and
maintenance of β-cell function. Targeted disruption of this transcription factor in β-cells leads
to diabetes, whereas reduced expression levels affect insulin expression and secretion.
Therefore, it is essential to determine molecular mechanisms underlying the regulation of
this key transcription factor on mRNA levels and, most importantly, on protein levels. Here
we show that a minor portion of IPF1/PDX1 is phosphorylated on serine 61 and/or serine 66 …
maintenance of β-cell function. Targeted disruption of this transcription factor in β-cells leads
to diabetes, whereas reduced expression levels affect insulin expression and secretion.
Therefore, it is essential to determine molecular mechanisms underlying the regulation of
this key transcription factor on mRNA levels and, most importantly, on protein levels. Here
we show that a minor portion of IPF1/PDX1 is phosphorylated on serine 61 and/or serine 66 …
