[HTML][HTML] Non‐hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia
X Zheng, W Li, Y Song, Y Hu, GL Ferrell… - Journal of Thrombosis …, 2007 - Elsevier
Summary Background: Activated protein C (APC) protects the host from severe sepsis.
Endothelial protein C receptor (EPCR) is expressed on both hematopoietic leukocytes and
non‐hematopoietic endothelium, and plays a key role in protein C activation. Objectives: We
explore the influence of EPCR deletion on the responses to lipopolysaccharide (LPS) and
then determine whether the observed differences are due to loss of hematopoietic or non‐
hematopoietic EPCR. Methods and results: After LPS challenge, EPCR null (Procr−/−) mice …
Endothelial protein C receptor (EPCR) is expressed on both hematopoietic leukocytes and
non‐hematopoietic endothelium, and plays a key role in protein C activation. Objectives: We
explore the influence of EPCR deletion on the responses to lipopolysaccharide (LPS) and
then determine whether the observed differences are due to loss of hematopoietic or non‐
hematopoietic EPCR. Methods and results: After LPS challenge, EPCR null (Procr−/−) mice …
