Novel immunogenic HLA-A* 0201-restricted epidermal growth factor receptor-specific T-cell epitope in head and neck cancer patients
PA Andrade Filho, A López-Albaitero… - Journal of …, 2010 - journals.lww.com
Therapeutic targeting of the epidermal growth factor receptor (EGFR), which is highly
overexpressed and correlated with poor prognosis in colorectal and head and neck
squamous cell carcinoma (SCCHN), has shown clinical efficacy using the blocking mAbs,
cetuximab or panitumumab, but only in 10% to 20% of patients. Clinical responsiveness is
correlated with certain Fcγ receptor genotypes, suggesting immune activity may contribute to
therapeutic efficacy. In addition, cetuximab-resistant tumor cells exhibit ubiquitination and …
overexpressed and correlated with poor prognosis in colorectal and head and neck
squamous cell carcinoma (SCCHN), has shown clinical efficacy using the blocking mAbs,
cetuximab or panitumumab, but only in 10% to 20% of patients. Clinical responsiveness is
correlated with certain Fcγ receptor genotypes, suggesting immune activity may contribute to
therapeutic efficacy. In addition, cetuximab-resistant tumor cells exhibit ubiquitination and …
