[HTML][HTML] Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL
JFP Berbée, CC van der Hoogt, D Sundararaman… - Journal of lipid …, 2005 - ASBMB
Studies in humans and mice have shown that increased expression of apolipoprotein CI
(apoC-I) results in combined hyperlipidemia with a more pronounced effect on triglycerides
(TGs) compared with total cholesterol (TC). The aim of this study was to elucidate the main
reason for this effect using human apoC-I-expressing (APOC1) mice. Moderate plasma
human apoC-I levels (ie, 4-fold higher than human levels) caused a 12-fold increase in TG,
along with a 2-fold increase in TC, mainly confined to VLDL. Cross-breeding of APOC1 mice …
(apoC-I) results in combined hyperlipidemia with a more pronounced effect on triglycerides
(TGs) compared with total cholesterol (TC). The aim of this study was to elucidate the main
reason for this effect using human apoC-I-expressing (APOC1) mice. Moderate plasma
human apoC-I levels (ie, 4-fold higher than human levels) caused a 12-fold increase in TG,
along with a 2-fold increase in TC, mainly confined to VLDL. Cross-breeding of APOC1 mice …