Vascular implications of the Kruppel-like family of transcription factors
T Suzuki, K Aizawa, T Matsumura… - … thrombosis, and vascular …, 2005 - Am Heart Assoc
T Suzuki, K Aizawa, T Matsumura, R Nagai
Arteriosclerosis, thrombosis, and vascular biology, 2005•Am Heart AssocThe Krüppel-like factor (KLF) family is a recently highlighted group of zinc finger
transcription factors given their important biological roles which include the vasculature.
KLF2, KLF4, KLF5, and KLF6 are notable factors that have been implicated in
developmental as well as pathological vascular processes. In this brief review, we provide
an up-to-date summary of the physiological functions and cellular effects as well as
transcriptional regulatory mechanisms of the vascular KLFs. Through such, we aim to …
transcription factors given their important biological roles which include the vasculature.
KLF2, KLF4, KLF5, and KLF6 are notable factors that have been implicated in
developmental as well as pathological vascular processes. In this brief review, we provide
an up-to-date summary of the physiological functions and cellular effects as well as
transcriptional regulatory mechanisms of the vascular KLFs. Through such, we aim to …
The Krüppel-like factor (KLF) family is a recently highlighted group of zinc finger transcription factors given their important biological roles which include the vasculature. KLF2, KLF4, KLF5, and KLF6 are notable factors that have been implicated in developmental as well as pathological vascular processes. In this brief review, we provide an up-to-date summary of the physiological functions and cellular effects as well as transcriptional regulatory mechanisms of the vascular KLFs. Through such, we aim to provide a working view for understanding the pathological actions of KLFs in the vasculature.
Am Heart Assoc
