[HTML][HTML] Evidence for a link between adipose tissue interleukin-6 content and serum C-reactive protein concentrations in obese subjects
JP Bastard, C Jardel, J Delattre, B Hainque… - Circulation, 1999 - Am Heart Assoc
JP Bastard, C Jardel, J Delattre, B Hainque, E Bruckert, F Oberlin
Circulation, 1999•Am Heart AssocWe read with interest the editorial by Tracy 1 on inflammation in cardiovascular disease
(CVD). Serum concentrations of C-reactive protein (CRP) were demonstrated to be related
to increased risk of CVD, which underlines the potential inflammatory nature of human
atherosclerosis. 2 3 Interestingly, an unexpected association between CRP and body mass
index (BMI) was found in several population studies 2 3 4 without any explanation. 1The
production of CRP is regulated by cytokines, principally interleukin-6 (IL-6), and serum CRP …
(CVD). Serum concentrations of C-reactive protein (CRP) were demonstrated to be related
to increased risk of CVD, which underlines the potential inflammatory nature of human
atherosclerosis. 2 3 Interestingly, an unexpected association between CRP and body mass
index (BMI) was found in several population studies 2 3 4 without any explanation. 1The
production of CRP is regulated by cytokines, principally interleukin-6 (IL-6), and serum CRP …
We read with interest the editorial by Tracy 1 on inflammation in cardiovascular disease (CVD). Serum concentrations of C-reactive protein (CRP) were demonstrated to be related to increased risk of CVD, which underlines the potential inflammatory nature of human atherosclerosis. 2 3 Interestingly, an unexpected association between CRP and body mass index (BMI) was found in several population studies 2 3 4 without any explanation. 1
The production of CRP is regulated by cytokines, principally interleukin-6 (IL-6), and serum CRP levels reflect IL-6 activity in humans. It was demonstrated that IL-6 is released in vivo by subcutaneous adipose tissue and is thereby able to have systemic effects, particularly in obese subjects. 5 Thus, we hypothesized that adipose tissue may play a role in the regulation of serum CRP concentrations via IL-6 production.
Am Heart Assoc
