[PDF][PDF] Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases
DL Dai, M Martinka, G Li - Journal of clinical oncology, 2005 - academia.edu
DL Dai, M Martinka, G Li
Journal of clinical oncology, 2005•academia.eduPurpose Akt is a serine/threonine kinase that leads to stimulation of cell cycle progression,
cell proliferation, and inhibition of apoptosis. To investigate the role of Akt in melanoma
pathogenesis, we examined the expression of phospho-Akt (p-Akt; Ser-473) in melanocytic
lesions at different stages and analyzed the correlations between the p-Akt expression level
and clinicopathologic factors and patient survival.
cell proliferation, and inhibition of apoptosis. To investigate the role of Akt in melanoma
pathogenesis, we examined the expression of phospho-Akt (p-Akt; Ser-473) in melanocytic
lesions at different stages and analyzed the correlations between the p-Akt expression level
and clinicopathologic factors and patient survival.
Purpose
Akt is a serine/threonine kinase that leads to stimulation of cell cycle progression, cell proliferation, and inhibition of apoptosis. To investigate the role of Akt in melanoma pathogenesis, we examined the expression of phospho-Akt (p-Akt; Ser-473) in melanocytic lesions at different stages and analyzed the correlations between the p-Akt expression level and clinicopathologic factors and patient survival.
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