Phosphorylation and activation of Ca2+-calmodulin-dependent protein kinase IV by Ca2+-calmodulin-dependent protein kinase Ia kinase: Phosphorylation of …
MA Selbert, KA Anderson, QH Huang… - Journal of Biological …, 1995 - ASBMB
Purified pig brain Ca 2+-calmodulin (CaM)-dependent protein kinase Ia kinase (Lee, JC,
and Edelman, AM (1994) J. Biol. Chem. 269, 2158-2164) enhances, by up to 24-fold, the
activity of recombinant CaM kinase IV in a reaction also requiring Ca 2+-CaM and MgATP.
The addition of brain extract, although capable of activating CaM kinase IV by itself, provides
no further activation beyond that induced by purified CaM kinase Ia kinase, consistent with
the lack of a requirement of additional components for activation. Activation is accompanied …
and Edelman, AM (1994) J. Biol. Chem. 269, 2158-2164) enhances, by up to 24-fold, the
activity of recombinant CaM kinase IV in a reaction also requiring Ca 2+-CaM and MgATP.
The addition of brain extract, although capable of activating CaM kinase IV by itself, provides
no further activation beyond that induced by purified CaM kinase Ia kinase, consistent with
the lack of a requirement of additional components for activation. Activation is accompanied …
