Vitronectin (Vn) is a major adhesive glycoprotein in blood. However, many of the functions of
Vn are regulated by its conformational state and degree of multimerization. Here, the ability
of native and denatured Vn to bind to integrin adhesion receptors was compared. Three
lines of evidence suggest that the native, plasma form of Vn is not an adhesive
glycoprotein.(i) Antibodies that bind in close proximity to the cell adhesion domain of Vn fail
to bind to native Vn present in unfractionated plasma.(ii) Denatured Vn binds to both …