Determinant selection for T-cell tolerance in HEL-transgenic mice: dissociation between immunogenicity and tolerogenicity
The induction of T-cell tolerance to self-antigens has been extensively characterized for
immunodominant (ID) regions. However, tolerance toward other minor self-determinants has
received less attention. In the H-2dhaplotype, HEL contains a single ID determinant (region
102–120) presented by I-EdMHC class II molecules. The present study evaluates the role of
subdominant and cryptic HEL regions in maintaining tolerance. We have generated a
mutated HEL antigen, HELμ, whose ID region does not bind to I-Ed. Lymph node cells from …
immunodominant (ID) regions. However, tolerance toward other minor self-determinants has
received less attention. In the H-2dhaplotype, HEL contains a single ID determinant (region
102–120) presented by I-EdMHC class II molecules. The present study evaluates the role of
subdominant and cryptic HEL regions in maintaining tolerance. We have generated a
mutated HEL antigen, HELμ, whose ID region does not bind to I-Ed. Lymph node cells from …
