Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.
H Cantor, J Hugenberger, L McVay-Boudreau… - The Journal of …, 1978 - rupress.org
H Cantor, J Hugenberger, L McVay-Boudreau, DD Eardley, J Kemp, FW Shen, RK Gershon
The Journal of experimental medicine, 1978•rupress.orgPurified Ly1 cells induce other T-cell sets to exert potent feedback inhibitory activity and this
TT interaction has been shown to play an important role in regulating in vivo immune
responses. Approximately 2/3 of Ly1 cells also express the Qa1 surface phenotype (Ly1:
Qa1+ cells). The experiments reported here indicate that Ly1: Qal+ cells are responsible for
induction of feedback inhibition and that signals from both Ly1: Qal+ cells and Ly1: Qal-cells
are required for optimal formation of antibody by B cells.
TT interaction has been shown to play an important role in regulating in vivo immune
responses. Approximately 2/3 of Ly1 cells also express the Qa1 surface phenotype (Ly1:
Qa1+ cells). The experiments reported here indicate that Ly1: Qal+ cells are responsible for
induction of feedback inhibition and that signals from both Ly1: Qal+ cells and Ly1: Qal-cells
are required for optimal formation of antibody by B cells.
Purified Ly1 cells induce other T-cell sets to exert potent feedback inhibitory activity and this T-T interaction has been shown to play an important role in regulating in vivo immune responses. Approximately 2/3 of Ly1 cells also express the Qa1 surface phenotype (Ly1:Qa1+ cells). The experiments reported here indicate that Ly1:Qal+ cells are responsible for induction of feedback inhibition and that signals from both Ly1:Qal+ cells and Ly1:Qal- cells are required for optimal formation of antibody by B cells.
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