[HTML][HTML] Induction of MHC-class I restricted human suppressor T cells by peptide priming in vitro
S Jiang, S Tugulea, G Pennesi, Z Liu, A Mulder… - Human immunology, 1998 - Elsevier
The induction of regulatory T cells may offer an effective means for specific
immunosuppression of autoimmune disease and allograft rejection. The existence of
suppressor T cells has been previously documented, yet their mechanism of action remains
poorly characterized. Our studies demonstrate that T suppressor (Ts) cell lines can be
generated by in vitro immunization of human PBMCs, with synthetic peptides or soluble
proteins coupled to beads. Such Ts cells express the CD8+ CD28− phenotype and show the …
immunosuppression of autoimmune disease and allograft rejection. The existence of
suppressor T cells has been previously documented, yet their mechanism of action remains
poorly characterized. Our studies demonstrate that T suppressor (Ts) cell lines can be
generated by in vitro immunization of human PBMCs, with synthetic peptides or soluble
proteins coupled to beads. Such Ts cells express the CD8+ CD28− phenotype and show the …