T-regulatory 1 cells: a novel subset of CD4+ T cells with immunoregulatory properties
MK Levings, MG Roncarolo - Journal of Allergy and Clinical Immunology, 2000 - Elsevier
Clonal deletion and clonal anergy are well established mechanisms of peripheral tolerance.
A role has also been described for clonal suppression by regulatory cells in the induction of
peripheral tolerance to a variety of antigens. However, it has been difficult to isolate
regulatory cells and to define their mechanism of action. We have recently reported the in
vitro generation and characterization of a novel subset of CD4+ T cells that have regulatory
properties and are able to suppress antigen-specific immune responses in vitro and in vivo …
A role has also been described for clonal suppression by regulatory cells in the induction of
peripheral tolerance to a variety of antigens. However, it has been difficult to isolate
regulatory cells and to define their mechanism of action. We have recently reported the in
vitro generation and characterization of a novel subset of CD4+ T cells that have regulatory
properties and are able to suppress antigen-specific immune responses in vitro and in vivo …