CD1 Recognition by Mouse NK1+ T Lymphocytes
Science, 1995•science.org
Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been
isolated from human blood, but it has not been determined whether these clones are part of
a defined subset of CD1-specific T cells selected during T cell development, or whether their
recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of αβ thymocytes
with a unique phenotype was found to be CD1-specific. This particular subset, and its
human counterpart, provide evidence that CD1 has a general role in selecting and …
isolated from human blood, but it has not been determined whether these clones are part of
a defined subset of CD1-specific T cells selected during T cell development, or whether their
recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of αβ thymocytes
with a unique phenotype was found to be CD1-specific. This particular subset, and its
human counterpart, provide evidence that CD1 has a general role in selecting and …
Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of CD1-specific T cells selected during T cell development, or whether their recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of αβ thymocytes with a unique phenotype was found to be CD1-specific. This particular subset, and its human counterpart, provide evidence that CD1 has a general role in selecting and interacting with specialized αβ T cells.
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