Publisher Summary This chapter discusses lentiviral vectors design and function and
discusses recent advances that improve their biosafety and demonstrate their potential for
gene delivery into important target tissues of gene therapy. Retroviral vectors have long
been favored for several reasons as gene transfer tools. First, they integrate efficiently into
the genome of the target cell. Second, they do not transfer any viral gene, thus alleviating the
risk of vector-mediated toxicity and immune response against the transduced cells. Both of …