Potent Tumor-initiating Activity of the 3,4-Dihydrodiol of 7,12-Dimethylbenz(a)anthracene in Mouse Skin
TJ Slaga, GL Gleason, J DiGiovanni, KB Sukumaran… - Cancer Research, 1979 - AACR
TJ Slaga, GL Gleason, J DiGiovanni, KB Sukumaran, RG Harvey
Cancer Research, 1979•AACRThe abilities of the racemic trans-3, 4-, 5, 6-, and 8, 9-dihydrodiols of 7, 12-dimethylbenz (a)
anthracene to initiate skin tumors in mice were determined by using a two-stage system of
tumorigenesis. The 7, 12-dimethylbenz (a) anthracene trans-3, 4-dihydrodiol was found to
be much more active as a tumor initiator than the parent hydrocarbon. The 7, 12-
dimethylbenz (a) anthracene trans-5, 6-and 8, 9-dihydrodiols were essentially inactive as
skin tumor initiators. Our results suggest that the 3, 4-dihydrodiol of 7, 12-dimethylbenz (a) …
anthracene to initiate skin tumors in mice were determined by using a two-stage system of
tumorigenesis. The 7, 12-dimethylbenz (a) anthracene trans-3, 4-dihydrodiol was found to
be much more active as a tumor initiator than the parent hydrocarbon. The 7, 12-
dimethylbenz (a) anthracene trans-5, 6-and 8, 9-dihydrodiols were essentially inactive as
skin tumor initiators. Our results suggest that the 3, 4-dihydrodiol of 7, 12-dimethylbenz (a) …
Abstract
The abilities of the racemic trans-3,4-, 5,6-, and 8,9-dihydrodiols of 7,12-dimethylbenz(a)anthracene to initiate skin tumors in mice were determined by using a two-stage system of tumorigenesis. The 7,12-dimethylbenz(a)anthracene trans-3,4-dihydrodiol was found to be much more active as a tumor initiator than the parent hydrocarbon. The 7,12-dimethylbenz(a)anthracene trans-5,6- and 8,9-dihydrodiols were essentially inactive as skin tumor initiators. Our results suggest that the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene is a proximal carcinogen and that the “bay region” diol-epoxide may be the ultimate carcinogenic form of DMBA.
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