Susceptibility to collagen-induced arthritis: cytokine-mediated regulation
RA Ortmann, EM Shevach - Clinical Immunology, 2001 - Elsevier
Collagen-induced arthritis is an animal model of inflammatory polyarthritis that is induced in
susceptible strains of rats and mice by intradermal immunization with heterologous type II
collagen emulsified in complete Freund's adjuvant. Previous studies have demonstrated that
disease induction is highly MHC-restricted, with only mice of H-2q or H-2r haplotypes being
susceptible. We have used a panel of both susceptible and resistant strains of mice in which
either IFN-γ or IL-10 signaling has been abolished by gene deletion and show that disease …
susceptible strains of rats and mice by intradermal immunization with heterologous type II
collagen emulsified in complete Freund's adjuvant. Previous studies have demonstrated that
disease induction is highly MHC-restricted, with only mice of H-2q or H-2r haplotypes being
susceptible. We have used a panel of both susceptible and resistant strains of mice in which
either IFN-γ or IL-10 signaling has been abolished by gene deletion and show that disease …
