[HTML][HTML] IKKα, IKKβ, and NEMO/IKKγ are each required for the NF-κB-mediated inflammatory response program
X Li, PE Massa, A Hanidu, GW Peet, P Aro… - Journal of Biological …, 2002 - ASBMB
The IKKβ and NEMO/IKKγ subunits of the NF-κB-activating signalsome complex are known
to be essential for activating NF-κB by inflammatory and other stress-like stimuli. However,
the IKKα subunit is believed to be dispensable for the latter responses and instead functions
as an in vivomediator of other novel NF-κB-dependent and-independent functions. In
contrast to this generally accepted view of IKKα's physiological functions, we demonstrate in
mouse embryonic fibroblasts (MEFs) that, akin to IKKβ and NEMO/IKKγ, IKKα is also a global …
to be essential for activating NF-κB by inflammatory and other stress-like stimuli. However,
the IKKα subunit is believed to be dispensable for the latter responses and instead functions
as an in vivomediator of other novel NF-κB-dependent and-independent functions. In
contrast to this generally accepted view of IKKα's physiological functions, we demonstrate in
mouse embryonic fibroblasts (MEFs) that, akin to IKKβ and NEMO/IKKγ, IKKα is also a global …
