[HTML][HTML] The NKG2D receptor and its ligands–recognition beyond the “missing self”?
C Watzl - Microbes and infection, 2003 - Elsevier
NKG2D is a surface receptor that activates natural killer (NK) cells and delivers a co-
stimulatory signal to CD8-positive T cells. The ligands of NKG2D are induced by cellular
stress and are specifically expressed by some tumor cells. This sparked the idea of an
alternative regulation of NK cells by expression of “induced self” ligands on target cells
which can overcome the inhibition imparted by MHC class I-specific inhibitory receptors.
stimulatory signal to CD8-positive T cells. The ligands of NKG2D are induced by cellular
stress and are specifically expressed by some tumor cells. This sparked the idea of an
alternative regulation of NK cells by expression of “induced self” ligands on target cells
which can overcome the inhibition imparted by MHC class I-specific inhibitory receptors.
