In vitro effects of cholecystokinin fragments on human gallbladders: evidence for an altered CCK-receptor structure in a subgroup of patients with gallstones
H Schneider, P Sänger, E Hanisch - Journal of hepatology, 1997 - Elsevier
Background/Aim: This study addresses cholecystokinin (CCK)-receptor alterations in stone-
diseased and stone-free human gallbladders using different CCK-fragments. Methods:
Serosa-free muscle strips were mounted in a modified Krebs-Henseleit-solution of 37° C
and aerated with carbogen. The following concentrations of CCK-fragments (CCK 26–33, N-
Acetyl CCK 27–33 sulf., CCK 26–29 sulf., CCK 25–33 sulf.) were achieved: 0.1 nmol, 0.5
nmol, 2 nmol, 10 nmol, 100 nmol. Results: Stone-diseased gallbladders were classified into …
diseased and stone-free human gallbladders using different CCK-fragments. Methods:
Serosa-free muscle strips were mounted in a modified Krebs-Henseleit-solution of 37° C
and aerated with carbogen. The following concentrations of CCK-fragments (CCK 26–33, N-
Acetyl CCK 27–33 sulf., CCK 26–29 sulf., CCK 25–33 sulf.) were achieved: 0.1 nmol, 0.5
nmol, 2 nmol, 10 nmol, 100 nmol. Results: Stone-diseased gallbladders were classified into …
