[HTML][HTML] Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice1
LP Duan, HH Wang, DQH Wang - Journal of lipid research, 2004 - ASBMB
In the present study, we investigated whether intestinal sterol efflux transporters Abcg5 and
Abcg8 play a major role in determining variations in cholesterol (Ch) absorption efficiency,
and we compared the physiological functions of the duodenal, jejunal, and ileal Abcg5 and
Abcg8 on the absorption of Ch and sitostanol in inbred mice challenged with various
amounts of Ch, sitostanol, hydrophilic, or hydrophobic bile acids. We found that Abcg5 and
Abcg8 in the jejunum and ileum, but not in the duodenum, were main factors in determining …
Abcg8 play a major role in determining variations in cholesterol (Ch) absorption efficiency,
and we compared the physiological functions of the duodenal, jejunal, and ileal Abcg5 and
Abcg8 on the absorption of Ch and sitostanol in inbred mice challenged with various
amounts of Ch, sitostanol, hydrophilic, or hydrophobic bile acids. We found that Abcg5 and
Abcg8 in the jejunum and ileum, but not in the duodenum, were main factors in determining …
