[HTML][HTML] Genetic factors at the enterocyte level account for variations inintestinal cholesterol absorption efficiency among inbred strains of mice1
DQH Wang, B Paigen, MC Carey - Journal of lipid research, 2001 - ASBMB
Interindividual and interstrain variations in cholesterol absorptionefficiency occur in humans
and animals. We investigated physiological biliaryand small intestinal factors that might
determine variations in cholesterolabsorption efficiency among inbred mouse strains. We
found that there weresignificant differences in cholesterol absorption efficiency measured by
plasma, fecal, and lymphatic methods:< 25% in AKR/J, C3H/J, and A/J strains; 25–30% in
SJL/J, DBA/2J, BALB/cJ, SWR/J, and SM/J strains; and31–40% in C57L/J, C57BL/6J, FVB/J …
and animals. We investigated physiological biliaryand small intestinal factors that might
determine variations in cholesterolabsorption efficiency among inbred mouse strains. We
found that there weresignificant differences in cholesterol absorption efficiency measured by
plasma, fecal, and lymphatic methods:< 25% in AKR/J, C3H/J, and A/J strains; 25–30% in
SJL/J, DBA/2J, BALB/cJ, SWR/J, and SM/J strains; and31–40% in C57L/J, C57BL/6J, FVB/J …
