[HTML][HTML] Glucose uptake and glycolysis reduce hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes
R Malhotra, FC Brosius - Journal of Biological Chemistry, 1999 - ASBMB
Myocardial ischemia/reperfusion is well recognized as a major cause of apoptotic or necrotic
cell death. Neonatal rat cardiac myocytes are intrinsically resistant to hypoxia-induced
apoptosis, suggesting a protective role of energy-generating substrates. In the present
report, a model of sustained hypoxia of primary cultures of Percoll-enriched neonatal rat
cardiac myocytes was used to study specifically the modulatory role of extracellular glucose
and other intermediary substrates of energy metabolism (pyruvate, lactate, propionate) as …
cell death. Neonatal rat cardiac myocytes are intrinsically resistant to hypoxia-induced
apoptosis, suggesting a protective role of energy-generating substrates. In the present
report, a model of sustained hypoxia of primary cultures of Percoll-enriched neonatal rat
cardiac myocytes was used to study specifically the modulatory role of extracellular glucose
and other intermediary substrates of energy metabolism (pyruvate, lactate, propionate) as …