[HTML][HTML] AP-1/Jun Is Required for Early Xenopus Development and Mediates Mesoderm Induction by Fibroblast Growth Factor but Not by Activin (∗)
In Xenopus, normal mesoderm formation depends on signaling through the fibroblast growth
factor (FGF) tyrosine kinase receptor. An important signaling pathway from receptor tyrosine
kinases involves Ras/Raf/MAP kinase. However, the downstream pathway that occurs in the
nucleus to finally trigger gene expression for mesoderm formation remains unknown. We
report here that a high level of activator protein-1 (AP-1)-dependent transcriptional activity is
detected during the early development of Xenopus embryos. Injection of a dominant …
factor (FGF) tyrosine kinase receptor. An important signaling pathway from receptor tyrosine
kinases involves Ras/Raf/MAP kinase. However, the downstream pathway that occurs in the
nucleus to finally trigger gene expression for mesoderm formation remains unknown. We
report here that a high level of activator protein-1 (AP-1)-dependent transcriptional activity is
detected during the early development of Xenopus embryos. Injection of a dominant …
