C3a-induced contraction of guinea pig lung parenchyma: role of cyclooxygenase metabolites
NP Stimler, CM Bloor, TE Hugli - Immunopharmacology, 1983 - Elsevier
The complement anaphylatoxin C3a from human or porcine serum contracts isolated
peripheral airways from guinea pig in a manner which is independent of histamine release.
In order to evaluate the role of arachidonic acid metabolites in the C3a response, dose-
response curves for C3a-induced contractions of guinea pig lung strips were compared in
the presence and absence of several inhibitors which block metabolism of arachidonic acid
at relatively specific steps in the pathways. The inhibitor of leukotriene activity, FPL 55712 …
peripheral airways from guinea pig in a manner which is independent of histamine release.
In order to evaluate the role of arachidonic acid metabolites in the C3a response, dose-
response curves for C3a-induced contractions of guinea pig lung strips were compared in
the presence and absence of several inhibitors which block metabolism of arachidonic acid
at relatively specific steps in the pathways. The inhibitor of leukotriene activity, FPL 55712 …
