[HTML][HTML] Cell type-specific protein-DNA interactions at the cAMP response elements of the prohormone convertase 1 promoter: evidence for additional transactivators …
E Jansen, TAY Ayoubi, SMP Meulemans… - Journal of Biological …, 1997 - ASBMB
The proximal promoter region of the neuroendocrine-specific human prohormone
convertase 1 (PC1) gene contains two distinct cAMP response elements (CRE-1 and CRE-
2). Both elements are essential in directing the cAMP-mediated hormonal regulation of PC1
gene transcription. In this study, we have demonstrated that CRE-1 binds several trans-
acting factors. In electrophoretic mobility shift assay experiments with nuclear extracts
prepared from neuroendocrine AtT-20 and β-TC3 cells and non-neuroendocrine COS-1 …
convertase 1 (PC1) gene contains two distinct cAMP response elements (CRE-1 and CRE-
2). Both elements are essential in directing the cAMP-mediated hormonal regulation of PC1
gene transcription. In this study, we have demonstrated that CRE-1 binds several trans-
acting factors. In electrophoretic mobility shift assay experiments with nuclear extracts
prepared from neuroendocrine AtT-20 and β-TC3 cells and non-neuroendocrine COS-1 …
