The pathology of the liver in alcoholic steatosis and alcoholic steatohepatitis (ASH) is
remarkably similar to that of nonalcoholic fatty liver disease (NAFLD), including nonalcoholic
steatohepatitis (NASH), suggesting some common pathogenic mechanism. Studies carried
out over the last three decades of possible mechanisms involved revealed one common link,
namely the induction of cytochrome P4502E1. Its substrates include fatty acids, ketones and
ethanol. These substances, when present chronically in large amounts, induce the activity of …