[HTML][HTML] Peroxisome proliferator-activated receptor α (PPARα) influences substrate utilization for hepatic glucose production
J Xu, G Xiao, C Trujillo, V Chang, L Blanco… - Journal of Biological …, 2002 - ASBMB
The hypoglycemia seen in the fasting PPARα null mouse is thought to be due to impaired
liver fatty acid β-oxidation. The etiology of hypoglycemia in the PPARα null mouse was
determined via stable isotope studies. Glucose, lactate, and glycerol flux was assessed in
the fasted and fed states in 4-month-old PPARα null mice and in C57BL/6 WT maintained on
standard chow using a new protocol for flux assessment in the fasted and fed states. Hepatic
glucose production (HGP) and glucose carbon recycling were estimated using [U-13 C 6] …
liver fatty acid β-oxidation. The etiology of hypoglycemia in the PPARα null mouse was
determined via stable isotope studies. Glucose, lactate, and glycerol flux was assessed in
the fasted and fed states in 4-month-old PPARα null mice and in C57BL/6 WT maintained on
standard chow using a new protocol for flux assessment in the fasted and fed states. Hepatic
glucose production (HGP) and glucose carbon recycling were estimated using [U-13 C 6] …
