[HTML][HTML] Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity
F Arakane, SR King, Y Du, CB Kallen, LP Walsh… - Journal of Biological …, 1997 - ASBMB
Steroidogenic acute regulatory protein (StAR) plays a critical role in steroid hormone
synthesis. StAR is thought to increase the delivery of cholesterol to the inner mitochondrial
membrane where P450scc resides. Tropic hormones acting through the intermediacy of
cAMP rapidly increase pregnenolone synthesis, and this rapid steroidogenic response is
believed to be due to StAR's action. The StAR protein contains two consensus sequences
for phosphorylation catalyzed by protein kinase A that are conserved across all species in …
synthesis. StAR is thought to increase the delivery of cholesterol to the inner mitochondrial
membrane where P450scc resides. Tropic hormones acting through the intermediacy of
cAMP rapidly increase pregnenolone synthesis, and this rapid steroidogenic response is
believed to be due to StAR's action. The StAR protein contains two consensus sequences
for phosphorylation catalyzed by protein kinase A that are conserved across all species in …