Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function
DA Bennett, JA Schneider, RS Wilson… - Archives of …, 2004 - jamanetwork.com
Objective To test the hypothesis that the association of amyloid load with clinical Alzheimer
disease (AD) and cognitive impairment is mediated through neurofibrillary tangles. Design
Longitudinal clinicopathologic cohort study. Participants and Setting Forty-four individuals
with clinically diagnosed AD and 53 without dementia who participated in the Religious
Orders Study underwent a uniform structured clinical evaluation for AD and cognitive testing
about 8 months prior to death, and brain autopsy at death. Methods The percent area …
disease (AD) and cognitive impairment is mediated through neurofibrillary tangles. Design
Longitudinal clinicopathologic cohort study. Participants and Setting Forty-four individuals
with clinically diagnosed AD and 53 without dementia who participated in the Religious
Orders Study underwent a uniform structured clinical evaluation for AD and cognitive testing
about 8 months prior to death, and brain autopsy at death. Methods The percent area …
