Primary structure, gene organization and polypeptide expression of poliovirus RNA
N Kitamura, BL Semler, PG Rothberg, GR Larsen… - Nature, 1981 - nature.com
N Kitamura, BL Semler, PG Rothberg, GR Larsen, CJ Adler, AJ Dorner, EA Emini…
Nature, 1981•nature.comThe primary structure of the poliovirus genome has been determined. The RNA molecule is
7,433 nucleotides long, polyadenylated at the 3′ terminus, and covalently linked to a small
protein (VPg) at the 5′ terminus. An open reading frame of 2,207 consecutive triplets spans
over 89% of the nucleotide sequence and codes for the viral polyprotein NCVPOO. Twelve
viral polypeptides have been mapped by amino acid sequence analysis and were found to
be proteolytic cleavage products of the polyprotein, cleavages occurring predominantly at …
7,433 nucleotides long, polyadenylated at the 3′ terminus, and covalently linked to a small
protein (VPg) at the 5′ terminus. An open reading frame of 2,207 consecutive triplets spans
over 89% of the nucleotide sequence and codes for the viral polyprotein NCVPOO. Twelve
viral polypeptides have been mapped by amino acid sequence analysis and were found to
be proteolytic cleavage products of the polyprotein, cleavages occurring predominantly at …
Abstract
The primary structure of the poliovirus genome has been determined. The RNA molecule is 7,433 nucleotides long, polyadenylated at the 3′ terminus, and covalently linked to a small protein (VPg) at the 5′ terminus. An open reading frame of 2,207 consecutive triplets spans over 89% of the nucleotide sequence and codes for the viral polyprotein NCVPOO. Twelve viral polypeptides have been mapped by amino acid sequence analysis and were found to be proteolytic cleavage products of the polyprotein, cleavages occurring predominantly at Gln-Gly pairs.
nature.com
