Oxygen sensing and signaling: impact on the regulation of physiologically important genes
H Zhu, HF Bunn - Respiration physiology, 1999 - Elsevier
A growing number of physiologically relevant genes are regulated in response to changes in
intracellular oxygen tension. It is likely that cells from a wide variety of tissues share a
common mechanism of oxygen sensing and signal transduction leading to the activation of
the transcription factor hypoxia-inducible factor 1 (HIF-1). Besides hypoxia, transition metals
(Co2+, Ni2+ and Mn2+) and iron chelation also promote activation of HIF-1. Induction of HIF-
1 by hypoxia is blocked by the heme ligands carbon monoxide and nitric oxide. There is …
intracellular oxygen tension. It is likely that cells from a wide variety of tissues share a
common mechanism of oxygen sensing and signal transduction leading to the activation of
the transcription factor hypoxia-inducible factor 1 (HIF-1). Besides hypoxia, transition metals
(Co2+, Ni2+ and Mn2+) and iron chelation also promote activation of HIF-1. Induction of HIF-
1 by hypoxia is blocked by the heme ligands carbon monoxide and nitric oxide. There is …
