Dendritic cells in antitumor immune responses: II. Dendritic cells grown from bone marrow precursors, but not mature DC from tumor-bearing mice, are effective …
DI Gabrilovich, S Nadaf, J Corak, JA Berzofsky… - Cellular …, 1996 - Elsevier
Antitumor CTL responses were studied in a model tumor bearing a mutant human p53 gene.
We found ineffective induction of antitumor CTL in mice bearing these tumors associated
with measurable defects in the function of dendritic cells (DC) from these animals. In this
study we investigate the mechanism of this defect in mature DC and find that functional DC
can be generated by growth from the bone marrow of tumor-bearing animals. Tumor cell
supernatants did not affect the function of mature DC obtained from the spleen of tumor …
We found ineffective induction of antitumor CTL in mice bearing these tumors associated
with measurable defects in the function of dendritic cells (DC) from these animals. In this
study we investigate the mechanism of this defect in mature DC and find that functional DC
can be generated by growth from the bone marrow of tumor-bearing animals. Tumor cell
supernatants did not affect the function of mature DC obtained from the spleen of tumor …