BAY K 8644-enhances immobility in the mouse behavioral despair test, an effect blocked by nifedipine
E Mogilnicka, A Czyrak, J Maj - European journal of pharmacology, 1988 - Elsevier
E Mogilnicka, A Czyrak, J Maj
European journal of pharmacology, 1988•ElsevierThe effect of the dihydropyridine calcium channel agonist, BAY K 8644 (0.05, 0.1, 0.5 mg/kg
ip), in the mouse behavioral despair test was investigated. BAY K 8644 dose dependently
prolonged the duration of immobility. The BAY K 8644 (0.1 mg/kg)-induced prolongation of
immobility was antagonized by the dihydropyridine calcium channel antagonist, nifedipine,
but not by the non-dihydropyridine type antagonist, verapamil and diltiazem. The effect of
BAY K 8644 was also antagonized by desipramine and imipramine but not by citalopram …
ip), in the mouse behavioral despair test was investigated. BAY K 8644 dose dependently
prolonged the duration of immobility. The BAY K 8644 (0.1 mg/kg)-induced prolongation of
immobility was antagonized by the dihydropyridine calcium channel antagonist, nifedipine,
but not by the non-dihydropyridine type antagonist, verapamil and diltiazem. The effect of
BAY K 8644 was also antagonized by desipramine and imipramine but not by citalopram …
Abstract
The effect of the dihydropyridine calcium channel agonist, BAY K 8644 (0.05, 0.1, 0.5 mg/kg i.p.), in the mouse behavioral despair test was investigated. BAY K 8644 dose dependently prolonged the duration of immobility. The BAY K 8644 (0.1 mg/kg)-induced prolongation of immobility was antagonized by the dihydropyridine calcium channel antagonist, nifedipine, but not by the non-dihydropyridine type antagonist, verapamil and diltiazem. The effect of BAY K 8644 was also antagonized by desipramine and imipramine but not by citalopram and iprindole. Therefore we suggest that central dihydropyridine binding sites play a role in despair behavior.
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