[HTML][HTML] GIPC interacts with the β1-adrenergic receptor and regulates β1-adrenergic receptor-mediated ERK activation
LA Hu, W Chen, NP Martin, EJ Whalen… - Journal of Biological …, 2003 - ASBMB
β 1-adrenergic receptors, expressed at high levels in the human heart, have a carboxyl-
terminal ESKV motif that can directly interact with PDZ domain-containing proteins. Using
the β 1-adrenergic receptor carboxyl terminus as bait, we identified the novel β 1-adrenergic
receptor-binding partner GIPC in a yeast two-hybrid screen of a human heart cDNA library.
Here we demonstrate that the PDZ domain-containing protein, GIPC, co-immunoprecipitates
with the β 1-adrenergic receptor in COS-7 cells. Essential for this interaction is the Ser …
terminal ESKV motif that can directly interact with PDZ domain-containing proteins. Using
the β 1-adrenergic receptor carboxyl terminus as bait, we identified the novel β 1-adrenergic
receptor-binding partner GIPC in a yeast two-hybrid screen of a human heart cDNA library.
Here we demonstrate that the PDZ domain-containing protein, GIPC, co-immunoprecipitates
with the β 1-adrenergic receptor in COS-7 cells. Essential for this interaction is the Ser …